Acute lymphoblastic leukemia (ALL) with KMT2A gene rearrangement in infants - characteristic clinical picture based on a case report
نویسندگان
چکیده
The most common malignancy affecting children is leukemia, which in infants refers to be diagnosed before 1 year of age and relatively rare, but remains a problem for clinicians due its aggressive clinical presentation, poor response current treatments, molecular biology. Infants with acute leukemia tend present features, including hyperleukocytosis, hepatosplenomegaly, central nervous system (CNS) involvement, cutaneous infiltration. In infant the KMT2A gene rearrangement at chromosome 11q23 quite common. harboring have particularly prognosis when compared other leukemia.
 A 10-month-old girl was admitted December 2017 Department Pediatric Hematology, Oncology Transplantology Lublin suspicion leukemia. One week hospitalization minor bruises began appear on skin, unrelated an injury. child hospital, there complete blood count showed anemia, hiperleukocytosis thorombocytopenia. On admission Clinic: severe general condition patient, features cardiopulmonary insufficiency were confirmed. Due patient's presence KMT2A/MLLT3-t(9;11) (p22;q23) rearrangement, stratified as high-risk group (HRG) chemotherapy started accordance therapeutic program.
 Infant one difficult situations encountered pediatric oncology. Given infant’s vulnerability unique genetic rearrangements, need develop new protocols therapies infants.
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ژورنال
عنوان ژورنال: Journal of Education, Health and Sport
سال: 2022
ISSN: ['2391-8306']
DOI: https://doi.org/10.12775/jehs.2022.12.03.022